The American Academy of Neurology in its most recent evidence-based review of the management of dementia summed up the evidence on AChEIs by stating: “Global changes in cognition, behavior, and functioning have been detected by both physicians and caregivers, indicating that even small, measurable differences may be clinically significant.”

Vitamin E likely delays the time to clinical worsening; selegiline, other antioxidants, anti-inflammatories, and estrogen require further study.