Neither food nor time of administration (morning vs evening dose) influences the rate or extent of absorption of donepezil. Rivastigmine is administered with food to reduce gastrointestinal side effects and improve tolerability by delaying absorption, prolonging time to maximal plasma concentration.

Galantamine is recommended to be given with food twice daily with morning and evening meals.

Currently available CHE-I have demonstrated linear dose-response relationships to varying degrees in clinical trials.

Here are the current dosage recommendations:

• Donepezil titration: 5mg at bedtime x 4-6 weeks, then increase to 10mg at bedtime.
• Rivastigmine titration: 1.5mg bid x 14 days, then 3mg bid x 14 days, then 4.5mg bid x 14 days, then 6mg bid
• Galantamine titration: 4 mg bid x 4 weeks, then 8 mg bid x 4 weeks, then if tolerated 12 mg bid (maximum total dose of 24 mg/day).